Dermatology
Our team's expertise in dermatology trials is rooted in a deep understanding of skin biology, immunology, and the nuances of patient-centered care.
We specialize in the design and execution of clinical trials across a wide range of dermatological conditions, ensuring high-quality data capture and patient safety.
Our clinical team have experience in:
- Psoriasis: Expertise in evaluating new treatments targeting immune pathways involved in chronic plaque psoriasis.
- Atopic Dermatitis: Proficiency in assessing novel therapies for this common and complex skin condition, including biologics and small molecules.
- Acne: Experience in conducting trials for both topical and systemic treatments, with a focus on reducing scarring and improving patient quality of life.
- Melanoma and Non-Melanoma Skin Cancers: Specialization in immuno-oncology approaches, targeted therapies, and combination treatments for skin cancer.
- Rare Dermatological Conditions: In-depth knowledge of conditions such as Epidermolysis Bullosa, Hidradenitis Suppurativa, and other rare skin diseases.
Pain points associated with clinical trials in dermatology
- Patient Recruitment and Retention: Identifying and engaging patients for dermatology trials, particularly those with rare or stigmatized conditions, can be difficult.
- Subjectivity of Skin Condition Assessments: Dermatological assessments often rely on visual inspections, which can be subjective and vary between evaluators.
- Placebo Effect: The visible nature of many skin conditions can lead to strong placebo responses, complicating the interpretation of trial results.
- Standardization of Scoring Systems: Ensuring consistency in the use of scoring systems such as PASI (Psoriasis Area and Severity Index) or EASI (Eczema Area and Severity Index) across multiple sites can be challenging.
- Safety Monitoring: Dermatology trials often involve long-term treatments, necessitating rigorous safety monitoring for adverse effects, especially in chronic conditions.
How iNGENū addresses these pain points
At iNGENū, we leverage our specialized knowledge and innovative approaches to overcome the challenges inherent in dermatology trials.
- Advanced Recruitment Strategies: We utilize targeted recruitment campaigns and partnerships with dermatology clinics and patient advocacy groups to identify and retain patients. Our patient-centric approach, including remote monitoring and teledermatology, enhances participation and reduces dropout rates.
- Objective Skin Assessments: To reduce subjectivity, we incorporate digital imaging technologies and automated analysis tools in our trials. We also provide thorough training for clinical evaluators to ensure consistent and accurate assessments.
- Robust Blinding and Statistical Techniques: iNGENū designs dermatology trials with rigorous blinding procedures and applies advanced statistical methods to mitigate placebo effects, ensuring the integrity of trial outcomes.
- Consistency in Scoring: We standardize the use of scoring systems across all sites, with regular calibration exercises and centralized review processes to ensure uniformity in data collection and analysis.
- Comprehensive Safety Monitoring: Our trials are supported by cutting-edge safety monitoring systems that track patient outcomes in real-time. We prioritize long-term safety, particularly for chronic dermatological conditions, ensuring that patients are protected throughout the study duration.